Periaqueductal Grey
PAG
Tissue
Cns
Where a threat becomes an action: freeze, flee or attack. It receives the amygdala's alarm and executes it. Relevant here because it explains why the reported anger is sudden and physical.
Relationships
2 connectionsPeriaqueductal Grey increases risk of
Aggression
Hostility and short fuse. Reported consistently by users and in case series, and produced in blinded trials mainly at supraphysiological doses and mainly in a minority of people.
Panic Attacks
Discrete episodes of overwhelming fear with a physical surge: pounding heart, breathlessness, a conviction that something is badly wrong. Different from sustained anxiety and worth its own entry because the plausible route is different too, running through sympathetic tone and a raised resting heart rate.