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Glutamate Signalling

Process Cns

The brain's main excitatory signal. Everything fast the brain does runs on it, and too much of it is how neurons die. Long-term users show a chemical signature consistent with raised turnover, which is the nearest thing to direct human evidence of a neurotoxic process in this literature.

Relationships

3 connections

Glutamate Signalling elevates

Anterior Cingulate Cortex

Where conflict is detected and effort is allocated. In long-term users this region shows a chemical signature of altered glutamate handling, which is the closest thing in the human literature to direct evidence of a neurotoxic process.

Glutamate Signalling increases risk of

Excitotoxic Injury

Death by over-stimulation. Glutamate opens calcium channels, calcium floods in past what the mitochondria can hold, and the cell triggers its own destruction. It is the final common path for a large share of neuronal death, and it is the exact process estrogen defends against.

Glutamate Signalling stimulates

Synaptic Plasticity

The brain's ability to strengthen and rebuild connections. It is what learning physically is, and it is the endpoint almost every nootropic peptide claims.

Beyond this page

Glutamate Signalling also connects to 3 entries in the applied modules, covering supplements, compounds, hormones and food sources. Those carry the mechanism and the evidence tier behind each link, and they are part of client coaching.

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